MGF (Mechano Growth Factor) is a splice variant of insulin-like growth factor-1 (IGF-1). Research reveals it to have positive effects on tissue growth, wound healing, cardiac repair, and skeletal muscle repair. There is good evidence to indicate that MGF improves muscle repair following injury and boosts recovery times following exercise or injury. MGF may even protect vulnerable tissue (e.g. cartilage) against mechanical stresses such occurs during running, weight training, and repetitive motion.
MGF Structure
G G His Ly -COOH
Thr Ser P P Gin Tyr -NH2
Primary sequence of MOF
Source: Researchgate
Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-
Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys
Molecular Formula:
Molecular Weight: 2971.99 g/mol
Synonyms: Mechano-growth factor, IGF-1Eb
IGF-I Alternative Splicing Creates MGF
Scientists have known about alternative splicing for some time now The
process refers to the ability of a cell to create mRNA strands in different ways to
produce a wide variety of proteins from the same basic DNA sequence. IGF-I
turns out to be on the extreme end ot altemative splicing. With six exons and
multiple transcription sites, IGE-I can be spliced into two classes consisting of
three major isoforms each (IGF-1Ea, IGF-1Eb, IGF-1Ec) for a total of at least
six different proteins. These peptides can then be further modified to produce
an even wider variety of altematives[l].
What Is MGF?
Mechano-growth factor is an altemative name for the IGF-I Eb isoform of IGF-I.
It has been shown to play important roles in muscle remodeling, cellular
proliferation, and cellular sutvival. New research suggests that this particular
isoform can also activate satellite cells in skeletal muscle, protect neurons, and
offset the muscle-wasting effects of aging[3].
The primary role of MGF is in muscle acute repair, particularly after exercise or
injury. Research in rats shows that concentrations of MGF increase dramatically
following muscle injury and that its presence in muscle correlates strongly iMth
skeletal muscle cell growth and differentiation[31.
MGF Research
MGF Levels Affected by Age
As it turns out, the specific versions of IGE-I that are produced depends on a
number of factors. Age, steroid hormones, growth hormone, and other
developmental cues all affect how IGE-I is spliced and the final peptides that
are produced. Age, in particular, has been found to have major influence on the
expression of IGE-I isoforms. Young men show now preference between class
1 and class 2 isoforms whereas older men show a statistically and
physiologically significant shift toward class 1 Ea[2]. The overall significance of
this change in terms of obvious signs of aging isn't dear, but it offers an
experimental starting point for understanding better the aging process. There is
some thought that MGF supplementation may be able to offset the muscle-
diminishing effects associated vÄth aging, though more research is required in
this area.
MGF Research Direction
MGF is being explored via a number of different research avenues. Right now,
the peptide shows a great deal of promise in protecting muscle tissue of all
types from a wide variety of insults- This makes MGF a prime candidate for
pharmaceutical development and the peptide may serve as the basis for a
number of breakthrough treatments over the next decade. Additionally, new
aspects of MGF are being uncovered regularly The peptide is already known to
protect neurons and boost cartilage health, so there is a wide area of
application for current and future research.
MGF exhibits minimal side effects, low oral and excellent subcutaneous
bioavailability in mice. Per kg dosage in mice does not scale to humans. MGF
for sale at Peptide Sciences is limited to educational and scientific research
only, not for human consumption Only buy MGF if you are a licensed
researcher.
Article Author
The above literature was researched, edited and organized by Dr. Logan, M.D.
Dc Logan holds a doctorate degree from Case Western Reserve University
School of Medicine and a B.S. in molecular biology.