Sermorelin
Sermorelin is a growth-hormone-releasing hormone (GHRH) analogue has been used to assess and stimulate natural growth hormone secretion. It is of interest to researchers for its ability to improve bone density, reduce scarring, fight the effects of dementia, and reduce seizure activity.
What Is Sermorelin?
Sermorelin IS one of a handful of growth hormone-releasing hormone (GHRH) analogues
that have been developed in recent years in an effort to preserve some of the positive
effects of natural GHRH while avoiding undesirable effects. Sermorelin (Geref) is
currently used clinically to assess growth hormone secretion, but the peptide is of
additional interest in its abilities to.
• reduce scarring following a heart attack,
• increase bone density,
• improve nutrition in chronic illness,
• improve renal function,
fight the effects of dementia, and
• reduce seizure activity.
Sermorelin Peptide Research
I. Sermorelin and Heart Health
Heart attack, while acutely life-threatening, can also lead to long-term disability
secondary to heart failure, cardiac conduction abnormalities (arrhythmias),
reduced exercise capacity, pain, and more. A number of these problems result
from cardiac remodeling that follows damage to myocytes (heart muscle cells).
Often, cardiac remodeling leads not only to scarring in the area of damage
following a heart attack, but in surrounding, undamaged areas as well. This
remodeling causes a number of long-term problems and research has shown
that preventing it from happening can significantly improve outcomes both
immediately after heart attack and years down the line.
In 2016, a study in pigs revealed that sermorelin administration is effective in
reducing the remodeling that follows a heart attack. The research showed that
sermorelin:
reduces cell death in cardiomyocytes,
• increases the production of extracellular matrix components needed for
adequate healing,
• increases the growth of blood vessels to damaged tissue, and
reduces the production of substances that causes damaging inflammation.
Clinically, sermorelin's effects are seen in improved diastolic function, reduced
scar size, and increased capillary grow'th[ll, There is current research
exploring the benefits of sermorelin in other forms of heart disease, such as
heart failure and even valve disorders.
GHRH treatment reduces scar mass- A Shows graph of percent change in scar
mass over time on top and the relationship between the percent change in scar
mass as a percentage of left ventricular mass. B. Shows images of the heart
before and after 4 weeks of sermorlin treatment or placebo.
2. Sermorelin and Epilepsy
Gamma-aminobutyric acid (GABA) is a central nervous system signaling
molecule known to reduce electrical activity in the spinal cord and reduce
overall electrical excitability in the central nervous system. A number of anti-
seizure medications work either by increasing levels of GABA in the central
nervous system or by binding to GABA receptors and mimicking the effects of
GABA In a recent study of mice with epilepsy, scientists administered GHRH
analogues, like sermorelin, to test the effect of these peptides on seizure
activity. It turns out that GHRH analogues are effective in suppressing seizures
by activating GABA receptorsm_ This is a very new finding and an active area of
research as medications for treating seizure conditions, while effective, have a
range of detrimental side effects that reduce their clinical use.
3. Sermorelin and Sleep
There is good evidence that sleep cycles are regulated by orexin , a potent
neurochemical produced by certain neurons in the brain. It is also well
understood that growth and healing, which are strongly associated with growth
hormone secretion, primarily take place during sleep. Research in rainbow trout
suggests that this is no coincidence, with an intact GHRH axis being a
necessary component for proper orexin secretion and function. In addition, the
research reveals that exogenous administration of sermorelin and other GHRH
agonists can boost orexin secretion There is ongoing research into the
benefits of using sermorelin in sleep disorders.
4. Sermorelin Preferred to Growth Hormone
Sermorelin is a growth hormone releasing hormone derivative and, as such,
produces all of the same effects that GH produces, including increasing muscle
mass, boosting long bone growth, and reducing adipose tissue- Even though
the effects are the same, the side effects are not. In fact, sermorelin is the
preferred way to increase GH levels in humans, even over the exogenous
administration of growth hormone itself. The primary reason for this preference
is that sermorelin is subject to physiological feedback mechanisms that help to
prevent common problems encountered with GH administration. These
problems include overdose, improper dosing, and unintended side effects like
edema, joint pain, and dysregulation of normal physiology[S].
A second reason to prefer sermorelin is that research shows it is not subject to
tachyphylaxis, the process by which the body becomes accustomed to a
medication and requires higher and higher doses to achieve desired effects. In
some cases, tachyphylaxis is so severe that a drug holiday (complete cessation
of use of a medication) is required to regain the effects of a medication. Long-
term use of sermorelin in certain clinical settings as well as animal studies of the
peptide indicate that the body has a unique response to the peptide. Rather
than down-regulate the production of GHRH receptors with administration of
sermorelin, the body instead increases their production. This ensures that
sermorelin's effects are unchanged, that tachyphylaxis does not develop to a
substantial degree, and that dose escalation is generally not requiredfl.
Sermorelin exhibits moderate side effects, low oral and excellent subcutaneous
bioavailability in mice- Per kg dosage in mice does not scale to
humans. Sermorelin for sale at Peptide Sciences is limited to educational and
scientific research only, not for human consumption. Only buy Sermorelin if you
are a licensed researcher.
Sermorelin is a growth hormone releasing hormone derivative and, as such,
produces all of the same effects that GH produces, including increasing muscle
mass, boosting long bone growth, and reducing adipose tissue- Even though
the effects are the same, the side effects are not. In fact, sermorelin is the
preferred way to increase GH levels in humans, even over the exogenous
administration of growth hormone itself. The primary reason for this preference
is that sermorelin is subject to physiological feedback mechanisms that help to
prevent common problems encountered with GH administration. These
problems include overdose, improper dosing, and unintended side effects like
edema, joint pain, and dysregulation of normal physiology[S].
A second reason to prefer sermorelin is that research shows it is not subject to
tachyphylaxis, the process by which the body becomes accustomed to a
medication and requires higher and higher doses to achieve desired effects. In
some cases, tachyphylaxis is so severe that a drug holiday (complete cessation
of use of a medication) is required to regain the effects of a medication. Long-
term use of sermorelin in certain clinical settings as well as animal studies of the
peptide indicate that the body has a unique response to the peptide. Rather
than down-regulate the production of GHRH receptors with administration of
sermorelin, the body instead increases their production. This ensures that
sermorelin's effects are unchanged, that tachyphylaxis does not develop to a
substantial degree, and that dose escalation is generally not requiredfl.
Sermorelin exhibits moderate side effects, low oral and excellent subcutaneous
bioavailability in mice- Per kg dosage in mice does not scale to
humans. Sermorelin for sale at Peptide Sciences is limited to educational and
scientific research only, not for human consumption. Only buy Sermorelin if you
are a licensed researcher.